Epigenetic control of Epstein–Barr virus transcription – relevance to viral life cycle?

DNA methylation normally leads to silencing of gene expression but Epstein–Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA methylation is absolutely required for the expression of many viral genes. Although the viral genome is initially un-methylated in newly infected cells, it becomes extensively methylated during the establishment of viral latency. One of the major regulators of EBV gene expression is a viral transcription factor called Zta (BZLF1, ZEBRA, Z) that resembles the cellular AP1 transcription factor. Zta recognizes at least 32 variants of a 7-nucleotide DNA sequence element, the Zta-response element (ZRE), some of which contain a CpG motif. Zta only binds to the latter class of ZREs in their DNA-methylated form, whether they occur in viral or cellular promoters and is functionally relevant for the activity of these promoters. The ability of Zta to interpret the differential DNA methylation of the viral genome is paramount for both the establishment of viral latency and the release from latency to initiate viral replication

Passing judgement: credit rating processes as regulatory mechanisms of governance in the emerging world order

This article argues that certain knowledge-producing institutions located in the American financial industry- debt security or bond rating agencies -are significant forces in the creation and extension of the new, open global political economy and therefore deserve the attention of international political economists as mechanisms of 'governance without government'. Rating agencies are hypothesized to possess leverage, based on their unique gate-keeping role with regard to investment funds sought by corporations and governments. The article examines trends in capital markets, the processes leading to bond rating judgements, assesses the form and extent of the agencies' governance powers, and contemplates the implications of these judgements for further extension of the global political economy and the form of the emerging world order

Effects of footwear variations on three-dimensional kinematics and tibial accelerations of specific movements in American football

American football is associated with a high rate of non-contact chronic injuries. Players are able to select from both high and low cut footwear. The aim of the current investigation was to examine the influence of high and low cut American football specific footwear on tibial accelerations and three-dimensional (3D) kinematics during three sport specific movements. Twelve male American football players performed three movements, run, cut and vertical jump whilst wearing both low and high cut footwear. 3D kinematics of the lower extremities were measured using an eight-camera motion analysis system alongside tibial acceleration parameters which were obtained using a shank mounted accelerometer. Tibial acceleration and 3D kinematic differences between the different footwear were examined using either repeated measures or Friedman’s ANOVA. Tibial accelerations were significantly greater in the low cut footwear in comparison to the high cut footwear for the run and cut movements. In addition, peak ankle eversion and tibial internal rotation parameters were shown to be significantly greater in the low cut footwear in the running and cutting movement conditions. The current study indicates that the utilization of low cut American football footwear for training/performance may place American footballers at increased risk from chronic injuries

Compatibility tests of materials for a lithium-cooled space power reactor concept

Materials for a lithium-cooled space power reactor concept must be chemically compatible for up to 50,000 hr at high temperature. Capsule tests at 1040 C (1900 F) were made of material combinations of prime interest: T-111 in direct contact with uranium mononitride (UN), Un in vacuum separated from T-111 by tungsten wire, UN with various oxygen impurity levels enclosed in tungsten wire lithium-filled T-111 capsules, and TZM and lithium together in T-111 capsules. All combinations were compatible for over 2800 hr except for T-111 in direct contact with UN

Fracture modes of high modulus graphite/epoxy angleplied laminates subjected to off-axis tensile loads

Angelplied laminates of high modulus graphite fiber/epoxy were studied in several ply configurations at various tensile loading angles to the zero ply direction in order to determine the effects of ply orientations on tensile properties, fracture modes, and fracture surface characteristics of the various plies. It was found that fracture modes in the plies of angleplied laminates can be characterized by scanning electron microscope observation. The characteristics for a given fracture mode are similar to those for the same fracture mode in unidirectional specimens. However, no simple load angle range can be associated with a given fracture mode

Compatibility of refractory materials for nuclear reactor poison control systems

Metal-clad poison rods have been considered for the control system of an advanced space power reactor concept studied at the NASA Lewis Research Center. Such control rods may be required to operate at temperatures of about 140O C. Selected poison materials (including boron carbide and the diborides of zirconium, hafnium, and tantalum) were subjected to 1000-hour screening tests in contact with candidate refractory metal cladding materials (including tungsten and alloys of tantalum, niobium, and molybdenum) to assess the compatibility of these materials combinations at the temperatures of interest. Zirconium and hafnium diborides were compatible with refractory metals at 1400 C, but boron carbide and tantalum diboride reacted with the refractory metals at this temperature. Zirconium diboride also showed promise as a reaction barrier between boron carbide and tungsten

The Middle Way versus Extremism

Extremism is a perennial problem in our civilisation. It has constantly impeded our progress by leading to unnecessary wars, conflicts, enmity and hatred. Understanding the middle way between these two extremes helps us to clarify what extremism is and how it arises. Such an understanding can be made part of the education system so that children are taught from an early age to detect extremist tendencies in their own thinking and to control them for their own good and the good of society. This paper extends the views expressed in my book, The Promise of Dualism (Almostic Publications) and other papers on the subject of extremism. It is focused on the following table which shows how the middle way stands between the extremes of too much power and too much belief. After the introduction, the rest of this paper explicates this table’s contents in considerable detail – line by line and word by word – in explanatory notes

Exploratory study of bend ductility of selected refractory metal weldments

Bending test for measuring ductility of refractory metal alloy weldment

Bend transition temperature of arc-cast molybdenum and molybdenum - 0.5-percent- titanium sheet in worked, recrystallized, and welded conditions

Bend transition temperature of arc-cast worked, recrystallized, and welded molybdenum and molybdenum-titanium alloy shee

The effects of shoe temperature on the kinetics and kinematics of running

The aim of the current investigation was to examine the effects of cooled footwear on the kinetics and kinematics of running in comparison to footwear at normal temperature. Twelve participants ran at 4.0 m/s ± 5% in both cooled and normal temperature footwear conditions over a force platform. Two identical footwear were worn, one of which was cooled for 30 min. Lower extremity kinematics were obtained using a motion capture system and tibial accelerations were measured using a triaxial accelerometer. Differences between cooled and normal footwear temperatures were contrasted using paired samples t-tests. The results showed that midsole temperature (cooled = 4.21 °C and normal = 23.25 °C) and maximal midsole deformation during stance (cooled = 12.85 mm and normal = 14.52 mm) were significantly reduced in the cooled footwear. In addition, instantaneous loading rate (cooled = 186.21 B.W/s and normal = 167.08 B W/s), peak tibial acceleration (cooled = 12.75 g and normal = 10.70 g) and tibial acceleration slope (cooled = 478.69 g/s and normal = 327.48 g/s) were significantly greater in the cooled footwear. Finally, peak eversion (cooled = −10.57 ° and normal = −7.83°) and tibial internal rotation (cooled = 10.67 ° and normal = 7.77°) were also shown to be significantly larger in the cooled footwear condition. This study indicates that running in cooled footwear may place runners at increased risk from the biomechanical parameters linked to the aetiology of injuries